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2-Imino-4-methylpiperidine(acetate)
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
2-Imino-4-methylpiperidine(acetate)图片
CAS NO:165383-72-2
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议

产品介绍
2-Imino-4-methylpiperidine (acetate) 是一种有效且具有口服活性的 NO 合酶 (NOS) 异构体抑制剂，IC50 为 0.1 μM, 1.1 μM, 和 0.2 ⋼M 对人 iNOS (hiNOS), heNOS hnNOS，分别。
Cas No.165383-72-2
别名2-亚氨基-4-甲基哌啶乙酸酯
化学名3,4,5,6-tetrahydro-4-methyl-2-pyridinamine, acetate
Canonical SMILESCC1CCN=C(N)C1.CC([O-])=O
分子式C6H12N2· C2H3O2
分子量171.2
溶解度≤5mg/ml in ethanol;5mg/ml in DMSO;5mg/ml in dimethyl formamide
储存条件Store at -20℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

2-Imino-4-methylpiperidine (acetate) is a potent NOS inhibitor [1]

Nitric oxide (NO) is an endogenously produced inorganic free radical gas which has been implicated in endothelium-dependent vascular relaxation, cell-to-cell communication, and cytotoxicity associated with phagocytic cells. NO is synthesized by three isoforms of nitric oxide synthase (NOS): nNOS, eNOS and iNOS [1].

2-Imino-4-methylpiperidine (acetate) is a 2-iminopiperidine class of NOS inhibitor. In the presence of a final L-arginine concentration of 30 μM, 2-Imino-4-methylpiperidine inhibited human iNOS, eNOS, and nNOS with IC50 values of 0.1, 1.1, and 0.2 μM, respectively. 2-Imino-4-methylpiperidine exhibited 9-fold and 1-fold selectivity for iNOS compared to eNOS and nNOS, respectively [1].

In LPS-treated rats, 2-Imino-4-methylpiperidine (10 mg/kg, po) inhibited plasma nitrite levels by 87%.

Reference:
[1].  Webber RK, Metz S, Moore WM, et al. Substituted 2-iminopiperidines as inhibitors of human nitric oxide synthase isoforms. J Med Chem. 1998 Jan 1;41(1):96-101.