| CAS NO: | 36889-13-1 |
| 包装 | 价格(元) |
| 5mg | 电议 |
| 10mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| Cas No. | 36889-13-1 |
| 别名 | L-N5-(1-亚胺乙基)-鸟氨酸盐酸盐 |
| 化学名 | N5-(1-iminoethyl)-L-ornithine, dihydrochloride |
| Canonical SMILES | CC(=N)NCCC[C@H](N)C(=O)O |
| 分子式 | C7H15N3O2o 2HCl |
| 分子量 | 246.1 |
| 溶解度 | ≤20mg/ml in ethanol;20mg/ml in DMSO;20mg/ml in dimethyl formamide |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | IC50: 1.7, 3.9, and 3.9 μM for nNOS (rat), eNOS (bovine), and iNOS (mouse), respectively L-NIO is a NOS inhibitor. Nitric oxide synthases (NOSs) are enzymes that catalyze the production of nitric oxide (NO) from L-arginine. NO is an important cellular signaling molecule and helps modulate vascular tone, airway tone, insulin secretion, and peristalsis. NO is involved in angiogenesis and neural development. In vitro: Three analogues of L-arginine were characterized as inhibitors of endothelial NO synthase by measuring their effect on the endothelial NO synthase from porcine aortae. It was found that L-NMMA, L-NIO and L-NAME could cause concentration-dependent inhibition of the Ca2+-dependent endothelial NO synthase [1]. In vivo: In rats, L-NMMA, L-NIO and L-NAME could induce a dose-dependent increase in mean systemic arterial blood pressure accompanied by bradycardia. Moreover, L-NMMA, L-NIO and L-NAME at i.v. 100 mg/kg significantly inhibited the hypotensive responses to ACh and bradykinin. The increase in blood pressure and bradycardia produced by these compounds were able to be reversed by L-arginine in a dose-dependent manner. Moreover, all of these effects were enantiomer specific [1]. Clinical trial: So far, no clinical study has been conducted. Reference: |
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