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Vitamin U chloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Vitamin U chloride图片
CAS NO:1115-84-0
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
S-Methylmethionine sulfonium chloride
产品介绍
Vitamin U (S-Methylmethionine sulfonium) chloride是一种具有抗氧化活性的口服抗溃疡剂。Vitamin U chloride 抑制脂肪细胞分化。Vitamin U chloride 可促进皮肤伤口愈合。Vitamin U chloride 可用于胃肠道溃疡的研究。
生物活性

Vitamin U (S-Methylmethionine sulfonium) chloride is an orally active anti-ulcer agent with antioxidant activity. Vitamin U inhibits adipocyte differentiation. Vitamin U promotes skin wound healing.Vitamin U can be used in the research of gastrointestinal ulceration[1][2][3][4][5].

体外研究
(In Vitro)

Vitamin U chloride (100 μM, 24 h) promotes the growth and migration of human dermal fibroblasts(hDFs)[1].
Vitamin U chloride (0-1 mM, 24 h) activates ERK1/2 in hDFs[1].
Vitamin U chloride (0.1 g/L in the nutrient solution) reduces cell membrane damage in higher plants exposed to low-temperature stress[2].
Vitamin U chloride (10-100 mM, 7 days) inhibits adipocyte differentiation via down-regulation of adipogenic factors and up-regulation of AMPK activity[3].

Cell Proliferation Assay[1]

Cell Line:Human dermal fibroblasts(hDFs)
Concentration:100 μM
Incubation Time:24 h
Result:Promoted hDFs proliferation.

Western Blot Analysis[3]

Cell Line:3T3-L1 cells
Concentration:50, 70, 90 mM
Incubation Time:7 days
Result:Increased AMPK phosphorylation and decreased PPAR-γ levels.
体内研究
(In Vivo)

Vitamin U chloride (50 mg/kg, oral gavage) prevents valproic acid-induced liver injury in rats[4].
Vitamin U chloride (50 mg/kg, oral gavage for 3 days) shows antioxidant effect and prevents GalN-induced gastric damage in rats[5].

Animal Model:Valproic acid (VPA)-induced rats with liver damage[4]
Dosage:50 mg/kg
Administration:Oral gavage
Result:Blocked the decrease in catalase (CAT), glutathione reductase (GR), glutathione peroxidase (GPx), and superoxide dismutase (SOD) activities.
Increased in the levels of IL-1β, active caspase-3, and cytoplasmic cytochrome c.
Increased in the number of proliferating cells nuclear antigen (PCNA) positive hepatocytes.
分子量

199.70

Formula

C6H14ClNO2S

CAS 号

1115-84-0

来源
  • Plants
  • Compositae
  • Wollastonia biflora(Linnaeus) Candolle
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.