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Flupenthixol dihydrochloride
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Flupenthixol dihydrochloride图片
CAS NO:2413-38-9
包装与价格:
包装价格(元)
10mM (in 1mL DMSO)电议
5mg电议
10mg电议

产品介绍
Flupentixol 是一种具有口服活性的 D1/D2 多巴胺受体拮抗剂和新型 PI3K 抑制剂(PI3Kα;IC50=127 nM)。
Cas No.2413-38-9
别名盐酸氟哌噻吨,Flupenthixol dihydrochloride
化学名(Z)-2-(4-(3-(2-(trifluoromethyl)-9H-thioxanthen-9-ylidene)propyl)piperazin-1-yl)ethanol dihydrochloride
Canonical SMILESFC(F)(C1=CC=C2SC3=CC=CC=C3/C(C2=C1)=C/CCN4CCN(CCO)CC4)F.Cl.Cl
分子式C23H25F3N2OS.2HCl
分子量507.44
溶解度<50.74mg/ml in Water;<25.37mg/ml in DMSO
储存条件Desiccate at RT
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

MIC: 10-100 μg/mL in most of the strains

Flupenthixol, introduced in 1965 by Lundbeck, marketed under brand names such asDepixol.Flupenthixolis atypical antipsychoticdrugof thethioxantheneclass. In addition to single drug preparations, flupenthixol is also available asflupentixol/melitracen, which is acombination product.

In vitro: The minimum inhibitory concentration of flupenthixol was determined by the National Committee for Clinical Laboratory Standards agar dilution method. MICs ranged from 10–100 μg/mL for most of the strains, whilst some strains were inhibited at even lower concentrations. The mode of action of flupenthixol was found to be bacteriostatic against Staphylococcus aureus and Vibrio cholerae [1].

In vivo: In the in vivo experiments, flupenthixol was able to contribute significant protection to a Swiss strain of white mice challenged with 50 median lethal dose of a mouse-virulent strain at a drug concentration of 15 μg/mouse. Moreover, flupenthixol reduced remarkably the number of viable bacteria in organs and blood of mice treated with flupenthixol [1].

Clinical trial: An clinical trial was carried out to evaluate the effectiveness and side-effects of flupenthixol treatment. The results showed that symptoms of depression, worrying, withdrawal, as well as psychomotor retardation were improved significantly with flupenthixol. Thus, it was concluded that schizophrenic patients characterized by depressive symptoms might more benefit to the flupenthixol treatment [2].

References:
[1] Jeyaseeli L,Gupta AD,Asok Kumar K,Mazumdar K,Dutta NK,Dastidar SG.  Antimicrobial potentiality of the thioxanthene flupenthixol through extensive in vitro and in vivo experiments. Int J Antimicrob Agents.2006 Jan;27(1):58-62.
[2] Kong DS,Yeo SH.  An open clinical trial with the long-acting neuroleptics flupenthixol decanoate and fluphenazine decanoate in the maintenance treatment of schizophrenia. Pharmatherapeutica.1989;5(6):371-9.