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Guanfu base I
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Guanfu base I图片
CAS NO:110225-59-7
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议

产品名称
Acorine
产品介绍
Guanfu base I (Acorine) 是 Guanfu base A 的活性代谢产物,是从Aconitum coreanum中分离得到的,具有很强的抗心律失常的作用。
生物活性

Guanfu base I (Acorine) is an active metabolite of Guanfu base A, isolated fromAconitum coreanum, and has a potent anti-arrhythmic effect[1].

体内研究
(In Vivo)

The pharmacokinetics of Guanfu base I in Sprague-Dawley rats is examined. The method is linear in the 0.05-20 μg/mL concentration range. The recovery of Guanfu base I is more than 80%. The intraday and interday precision, expressed as the relative standard deviation, is generally good. After intravenous injection dosing, plasma Guanfu base I concentration declined in a bi-phasic manner with a terminal elimination half-life of 2.49 hours. The total plasma clearance value is 1.46 L/h/kg. After oral dosing, the plasma Guanfu base I concentration reached a maximum within 0.5 hour. The absolute bioavailability of Guanfu base I is 71.31%[1].

分子量

387.47

Formula

C22H29NO5

CAS 号

110225-59-7

结构分类
  • Alkaloids
  • Indole Alkaloids
来源
  • Plants
  • Ranunculaceae
  • Aconitum coreanum(Lévl.) Rapaics
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.