Clobenpropit

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Clobenpropit

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

CAS NO:

145231-45-4

包装与价格：

包装	价格(元)
100mg	电议
250mg	电议
500mg	电议

产品介绍

Clobenpropit 是一种有效的组胺 H3 受体 (histamine H3-receptor

生物活性

Clobenpropit is a potenthistamine H3-receptorantagonist. Clobenpropit decreases dopamine release and increases histamine levels in the hypothalamus. Clobenpropit shows antipsychotic-like activities. Clobenpropit causes a resuscitating effect in rats subjected to the hemorrhagic shock^[1]^[2].

IC₅₀& Target^[1]

H₃receptor

体内研究
(In Vivo)

Clobenpropit (15 mg/kg；腹腔注射；每天一次，持续 7 天) 可抵消MK-801(HY-15084B) 对多巴胺和组胺水平的调节作用，并防止 MK-801 诱导的过度运动行为^[1]。< br/>Clobenpropit (1、2、5 μmoL/kg；静脉注射) 对遭受失血性休克的大鼠产生复苏作用^[2]。

Animal Model:	150-200g, 12-week-old male wistar albino rats^[1]
Dosage:	15 mg/kg
Administration:	I.p.; once daily for 7 days
Result:	Exhibited a significant reduction of hyperlocomotor activities induced by a single-dose administration of MK-801 (0.2 mg/kg, i.p.), and reduced the MK-801-induced dopamine release, exhibited further increase in histamine levels in the hypothalamus.

Animal Model:	205-470g, adult male Wistar rats^[2]
Dosage:	1, 2, 5 μmoL/kg (after 6-hydroxydopamine (50 mg/kg (SC) for 3 consecutive days)
Administration:	I.v.
Result:	Triggered a statistically significant increase of mean arterial pressure (MAP) (dose 2 μmol/kg) and heart rate (HR) (doses of 1, 2, 5 μmol/kg).

分子量

308.83

Formula

C₁₄H₁₇ClN₄S

CAS 号

145231-45-4

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.