L-Phenylalanine-d8 ((S)-2-Amino-3-phenylpropionic acid-d8) is the deuterium labeled L-Phenylalanine. L-Phenylalanine ((S)-2-Amino-3-phenylpropionic acid) is an essential amino acid isolated fromEscherichia coli. L-Phenylalanine is aα2δ subunit of voltage-dependent Ca⁺channelsantagonist with aK_iof 980 nM. L-phenylalanine is a competitive antagonist for the glycine- and glutamate-binding sites ofN-methyl-D-aspartate receptors (NMDARs)(K_Bof 573 μM ) andnon-NMDARs, respectively. L-Phenylalanine is widely used in the production of food flavors and pharmaceuticals^[1][2][3][4].

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

173.24

Solid

C₉H₃D₈NO₂

17942-32-4

L-苯丙氨酸 d8

Room temperature in continental US; may vary elsewhere.