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Dithiodipropionic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dithiodipropionic acid图片
CAS NO:1119-62-6
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
3,3'-二硫代二丙酸
产品介绍
Dithiodipropionic acid 可与 CPUL1 (HY-151802,TrxR抑制剂) 相互作用 形成纳米聚集体 (CPUL1-DA NAs)。CPUL1-DA NAs 可比游离 CPUL1 产生更丰富的活性氧 (ROS) 并诱导细胞凋亡 (apoptosis),提高抗 HUH7 癌细胞的抗肿瘤功效。
生物活性

Dithiodipropionic acid can interact withCPUL1(HY-151802, aTrxRinhibitor) to form nanoaggregates (CPUL1-DA NAs). CPUL1-DA NAs generates more abundantROSto induce cellapoptosisthan that of free CPUL1, and improves antitumor efficacy against HUH7cancercells[1].

体外研究
(In Vitro)

CPUL1-DA NAs (molar ratio was 1:2) inhibits HUH7 hepatoma cell viability with an IC50value of 4.3 μM, and has weak cytotoxicity against normal L02 cells[1].
CPUL1-DA NAs (2.5-10 μM, 6 h) can be more effectively enriched in HUH7 cells mitochondria and displays faster cellular uptake ability to deliver CPUL1 into cells than that of free CPUL1[1].
CPUL1-DA NAs (2.5-10 μM, 12 h) results in the accumulation of superoxides and mitochondrial membrane damage in HUH7 cells[1].

分子量

210.26

性状

Solid

Formula

C6H10O4S2

CAS 号

1119-62-6

中文名称

3,3'-二硫代二丙酸

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder-20°C3 years
4°C2 years
In solvent-80°C6 months
-20°C1 month