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Ipratropium Bromide
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
Ipratropium Bromide图片
CAS NO:22254-24-6
包装与价格：
包装价格(元)
10mM (in 1mL DMSO)电议
50mg电议

产品介绍
Ipratropium bromide (Sch 1000) 是一种毒蕈碱受体拮抗剂，对 M1、M2 和 M3 受体的 IC50 分别为 2.9 nM、2 nM 和 1.7 nM。
Cas No.22254-24-6
别名异丙托溴铵; Sch 1000
化学名(8-methyl-8-propan-2-yl-8-azoniabicyclo[3.2.1]octan-3-yl) 3-hydroxy-2-phenylpropanoate;bromide
Canonical SMILESCC(C)[N+]1(C2CCC1CC(C2)OC(=O)C(CO)C3=CC=CC=C3)C.[Br-]
分子式C20H30BrNO3
分子量412.37
溶解度≥ 20.62mg/mL in DMSO
储存条件Store at 2-8℃
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Ipratropium Bromide is a muscarinic antagonist, bronchodilator, N-Isopropyl salt of atropine.Target: mAChRIpratropium bromide, a nonselective muscarinic antagonist, is widely prescribed for the treatment of chronic obstructive pulmonary disease (COPD). In anaesthetised guinea-pigs, bronchoconstriction induced by vagal nerve stimulation was potentiated by low doses of the antimuscarinic bronchodilator drug, ipratropium (0.01-1.0 g/kg); the maximum effect was obtained with 1.0 g/kg which doubled the bronchoconstriction. When the dose was increased above 1.0 g/kg potentiation no longer occurred; instead the vagally induced bronchoconstriction was antagonized [1, 2].

References:
[1]. Fryer, A.D. and J. Maclagan, Ipratropium bromide potentiates bronchoconstriction induced by vagal nerve stimulation in the guinea-pig. Eur J Pharmacol, 1987. 139(2): p. 187-91.
[2]. Harvey, K.L., A. Hussain, and H.L. Maddock, Ipratropium Bromide-Mediated Myocardial Injury in In Vitro Models of Myocardial Ischaemia/Reperfusion. Toxicol Sci, 2014.