包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | IRAK4-IN-18 is a potentinterleukin-1 receptor-associated kinase 4 (IRAK4)inhibitor with anIC50value of 15 nM. IRAK4-IN-18 can inhibit LPS-induced IL23 production in THP and DC cells, and stop arthritis development in arthritis rats. IRAK4-IN-18 can be used for researching arthritis disease[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | IRAK4-IN-18 (compound 33) has inhibitory activity against LPS-induced IL23 in THP and DC with IC50s of 0.25 and 0.14 μM, respectively[1]. | ||||||||
体内研究 (In Vivo) | IRAK4-IN-18 (5, 10 and 20 mg/kg; twice daily for 21 days) exhibits good efficacy in a mouse model for the inhibition of IL-6 production induced by IL-1β, and completely stops arthritis development in arthritis rats at 30 mg/kg[1].
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分子量 | 464.49 | ||||||||
Formula | C24H25FN6O3 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |