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Hispolon
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Hispolon图片
CAS NO:173933-40-9
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍
Hispolon 是一种多酚,可从桑黄 (Phellinus linteus) 中分离得到。Hispolon 具有抗癌、抗糖尿病、抗氧化、抗病毒、肝保护活性、抗糖尿病和抗炎活性。
生物活性

Hispolon, a polyphenol, can be isolated fromPhellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities[1].

体外研究
(In Vitro)

Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells[2].
Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells[2].
Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21[2].
Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells[2].

Cell Viability Assay[2]

Cell Line:U87MG cells
Concentration:25 and 50 μM
Incubation Time:24, 48, 72 h
Result:Inhibited cell viability in a dose and time dependent way.

Western Blot Analysis[2]

Cell Line:U87MG cells
Concentration:25 and 50 μM
Incubation Time:2, 4, 8 h
Result:Decreased cyclin D4 level, and increased p21 level.
体内研究
(In Vivo)

Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice[3].
Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice[4].

Animal Model:LPS-induced acute lung injury mice[3]
Dosage:2.5, 5 and 10 mg/kg
Administration:Intraperitoneal injection (i.p.)
Result:Alleviated the pathological effects in the LPS-challenged mouse.
Reduced the W/D ratio in the lung and MPO activity.
Decreased pro-Inflammatory cytokine production.
Animal Model:DBTRG xenograft mice[4]
Dosage:5 and 10 mg/kg
Administration:Subcutaneous injection (s.c.)
Result:Reduced tumor volume (RTV).
Inhibited GBM cell proliferationin vivoupon HE and ki-67 staining.
分子量

220.22

性状

Solid

Formula

C12H12O4

CAS 号

173933-40-9

结构分类
  • Phenols
  • Polyphenols
来源

Phellinus linteus

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

DMSO : 125 mg/mL(567.61 mM;ultrasonic and warming and heat to 70℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM4.5409 mL22.7046 mL45.4091 mL
5 mM0.9082 mL4.5409 mL9.0818 mL
10 mM0.4541 mL2.2705 mL4.5409 mL
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。