Hispolon 是一种多酚,可从桑黄 (Phellinus linteus) 中分离得到。Hispolon 具有抗癌、抗糖尿病、抗氧化、抗病毒、肝保护活性、抗糖尿病和抗炎活性。
生物活性 | Hispolon, a polyphenol, can be isolated fromPhellinus linteus. Hispolon possesses anticancer, antidiabetic, antioxidant, antiviral, hepatoprotective, anti-diabetic, and anti-inflammatory activities[1]. |
体外研究 (In Vitro) | Hispolon (25 and 50 μM, 24-72 h) inhibits cell viability of U87MG cells[2]. Hispolon (25 and 50 μM, 24, 48 h) induces G2/M cell cycle arrest and apoptosis in U87MG cells[2]. Hispolon (25 and 50 μM, 2-8 h) decreases the expression of G1–S transition-related protein cyclin D4 but increases the expression of CDK inhibitor p21[2]. Hispolon (25 and 50 μM, 24 h) inhibits the migration of U87MG cells[2].
Cell Viability Assay[2] Cell Line: | U87MG cells | Concentration: | 25 and 50 μM | Incubation Time: | 24, 48, 72 h | Result: | Inhibited cell viability in a dose and time dependent way. |
Western Blot Analysis[2] Cell Line: | U87MG cells | Concentration: | 25 and 50 μM | Incubation Time: | 2, 4, 8 h | Result: | Decreased cyclin D4 level, and increased p21 level. |
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体内研究 (In Vivo) | Hispolon (2.5-10 mg/kg, i.p.) attenuates LPS-induced acute lung injury in mice[3]. Hispolon (5 and 10 mg/kg, s.c.) reduces tumor growth in DBTRG xenograft mice[4].
Animal Model: | LPS-induced acute lung injury mice[3] | Dosage: | 2.5, 5 and 10 mg/kg | Administration: | Intraperitoneal injection (i.p.) | Result: | Alleviated the pathological effects in the LPS-challenged mouse. Reduced the W/D ratio in the lung and MPO activity. Decreased pro-Inflammatory cytokine production. |
Animal Model: | DBTRG xenograft mice[4] | Dosage: | 5 and 10 mg/kg | Administration: | Subcutaneous injection (s.c.) | Result: | Reduced tumor volume (RTV). Inhibited GBM cell proliferationin vivoupon HE and ki-67 staining. |
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运输条件 | Room temperature in continental US; may vary elsewhere. |
储存方式 | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
溶解性数据 | In Vitro: DMSO : 125 mg/mL(567.61 mM;ultrasonic and warming and heat to 70℃) 配制储备液 1 mM | 4.5409 mL | 22.7046 mL | 45.4091 mL | 5 mM | 0.9082 mL | 4.5409 mL | 9.0818 mL | 10 mM | 0.4541 mL | 2.2705 mL | 4.5409 mL |
*请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。 |