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Tiprelestat
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:820211-82-3
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
Tiprelestat 是一种有效的人类中性粒细胞弹性蛋白酶 (elastase) 抑制剂。Tiprelestat 具有抗菌和抗炎活性。Tiprelestat 可用于炎症/免疫疾病的研究。
生物活性

Tiprelestat is a potent human neutrophilelastaseinhibitor. Tiprelestat has antimicrobial and anti-inflammatory activities. Tiprelestat can be used in the research of inflammation/immune disease[1].

体外研究
(In Vitro)

Tiprelestat (4 and 8 μM) inhibitsP. aeruginosa-secreted peptidase[3].
Tiprelestat (10 μg/mL, 1 h) inhibits LPS-induced MCP-1 production in U937 cells[4].
Tiprelestat (10 μg/mL, 1 h) down-regulates LPS-induced AP-1 and NF-κB activation in U937 cells[4].

Western Blot Analysis[4]

Cell Line:U937 cells
Concentration:10 μg/mL
Incubation Time:1 h
Result:Prevented LPS-induced degradation of IκBα, IκBβ, and IRAK.
体内研究
(In Vivo)

Tiprelestat (1 mg/kg, intranasal inhalation) suppresses lung elastase activity and apoptosis in MV-O2mice[2].
Tiprelestat (0.2 mg/kg, s.c. for 2 weeks) attenuates hypoxic pulmonary hypertension in mice[5].

Animal Model:Mice, treated with Mechanical ventilation with O2-rich gas[2]
Dosage:1 mg/kg
Administration:Intranasal inhalation
Result:Increased the lung abundance of nuclear Klf4 protein.
Animal Model:Su/Hx rat model[5]
Dosage:0.2 mg/kg
Administration:Subcutaneous injection (s.c.), daily for 2 weeks.
Result:Reduced elastase activity and reversed pulmonary hypertension.
Clinical Trial
分子量

5999.09

Formula

C254H416N72O75S10

CAS 号

820211-82-3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.