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DHQZ 36
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
DHQZ 36图片
CAS NO:1542098-94-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品介绍
DHQZ 36 是一种逆行运输的有效抑制剂。DHQZ 36 以EC50值为13.63 μM 来抑制巨噬细胞中Leishmania amazonensis的感染。DHQZ 36 具有有效的抗寄生虫活性。
生物活性

DHQZ 36 is a potent inhibitor of retrograde trafficking. DHQZ 36 inhibitsLeishmaniaamazonensisinfectionin macrophages with anEC50of 13.63 μM. DHQZ 36 has potent anti-parasite activity[1].

IC50& Target

EC50: 13.63 μM (Leishmania amazonensis)[1]

体外研究
(In Vitro)

With increasing concentrations of DHQZ 36 there is a significant diminution in the size of parasitophorous vacuoles (LPVs), vacuole sizes are reduced by 30% at 50 μM. These parasites also cause a reduction in the number of parasites per macrophage. Significant parasite loss is observed with as low as 5 μM after treatment with DHQZ 36. Parasites are unable to recover growth when treated with DHQZ 36 at concentrations at or above 12.5 μM[1].
DHQZ 36 causes over 40% reduction in secreted of parasite proteins. DHQZ 36 causes a reversal inLeishmaniainduced suppression of IL-6 release by infected cells after LPS activation[1].

分子量

384.44

Formula

C21H18F2N2OS

CAS 号

1542098-94-1

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.