CAS NO: | 2175953-98-5 |
包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Tau-aggregation and neuroinflammation-IN-1 is a potenttau-aggregationandneuroinflammationinhibitor. Tau-aggregation and neuroinflammation-IN-1 exhibits remarkable inhibitory activities against AcPHF6 and full-length tau aggregation. Tau-aggregation and neuroinflammation-IN-1 has a low cytotoxicity and reducedNOrelease in LPS-stimulated BV2 cells. Tau-aggregation and neuroinflammation-IN-1 can reverse okadaic acid-induced memory impairment in rats[1]. | ||||||||
IC50& Target | AcPHF6, tau-aggregation, NO[1] | ||||||||
体外研究 (In Vitro) | Tau-aggregation and neuroinflammation-IN-1 (compound 30) (0-40 μM) reduces the survival of SH-SY5Y cells at 30 μM, and exerts no significant hepatotoxicity in LO2 cells at high concentrations, also exerts no effect on BV2 cell viability at 20 μM[1]. Cell Cytotoxicity Assay
| ||||||||
体内研究 (In Vivo) | Tau-aggregation and neuroinflammation-IN-1 (5 and 10 mg/kg; for 14 days) leads to a substantial improvement of the conventional reference spatial memory and cognitive abilities of OA-induced rats[1].
| ||||||||
分子量 | 460.44 | ||||||||
Formula | C25H20N2O7 | ||||||||
CAS 号 | 2175953-98-5 | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |