CAS NO: | 3543-75-7 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
25mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
1 g | 电议 |
5 g | 电议 |
生物活性 | Bendamustine hydrochloride (SDX-105), a purine analogue, is aDNA cross-linkingagent. Bendamustine hydrochloride activats DNA-damage stress response andapoptosis. Bendamustine hydrochloride has potent alkylating, anticancer and antimetabolite properties[1]. | ||||||||||||||||
IC50& Target | DNA Alkylator/Crosslinker[1] | ||||||||||||||||
体外研究 (In Vitro) | Bendamustine is a DNA cross-linking agent that causes DNA breaks, with alkylating and antimetabolite properties. Bendamustine uniquely regulates apoptosis pathways and DNA repair pathways in non-Hodgkin's lymphoma cells. Bendamustine (50 μM) induces p21 (Cip1/Waf1) and NOXA genes, and increases the expression of p53 in SU-DHL-1 cells. Bendamustine (25 μM) blocks mitotic checkpoints and cuases mitotic catastrophe[1]. | ||||||||||||||||
体内研究 (In Vivo) | Bendamustine (25 mg/kg, i.v.) shows potent inhibition on the growth of tumor cells by 91%, 99% and 95% for DoHH-2, Granta 519 and RAMOS models, respectively. Moreover, the antitumor effect of Bendamustine is enhanced by rituximab in DoHH-2 and RAMOS models, but not in Granta 519 model[3]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 394.72 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C16H22Cl3N3O2 | ||||||||||||||||
CAS 号 | 3543-75-7 | ||||||||||||||||
中文名称 | 盐酸苯达莫司汀 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) | ||||||||||||||||
溶解性数据 | In Vitro: DMSO : 100 mg/mL(253.34 mM;Need ultrasonic) H2O : 12.5 mg/mL(31.67 mM;Need ultrasonic) 配制储备液
* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 In Vivo: 请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照In Vitro方式配制澄清的储备液,再依次添加助溶剂: ——为保证实验结果的可靠性,澄清的储备液可以根据储存条件,适当保存;体内实验的工作液,建议您现用现配,当天使用;
以下溶剂前显示的百
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