包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Antitumor agent-86 (compound 5a) inhibits MCF-7 breastcancercells with anIC50value of 2.62 μM. Antitumor agent-86 induces cellapoptosisand cell cycle arrest, and shows antineoplastic activity by targetingRAS/PI3K/Akt/JNKsignaling cascades[1]. | ||||||||||||||||||||||||
体外研究 (In Vitro) | Antitumor agent-86 (0-200 μM;48 h) 剂量依赖性地抑制 MCF-7,MDA-MB-231,Caco-2 和 PANC-1 癌细胞的增殖,IC50值分别为 2.617、6.778、14.8 和 23.58 μM[1]。Antitumor agent-86 (2.62 μM;48 h) 诱导细胞凋亡、细胞周期阻滞,降低 MCF-7 细胞的 p-RAS蛋白水平、PI3K 和 Akt 的 mRNA 转录水平和 p-JNK 蛋白的表达[1]。Antitumor agent-86 (2.62 μM;48 h) 上调 p21 基因的表达水平[1]。 Cell Proliferation Assay[1]
Western Blot Analysis[1]
Apoptosis Analysis[1]
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分子量 | 513.65 | ||||||||||||||||||||||||
Formula | C29H31N5O2S | ||||||||||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |