CAS NO: | 491833-29-5 |
包装 | 价格(元) |
10 mM * 1 mL in DMSO | 电议 |
1mg | 电议 |
5mg | 电议 |
10mg | 电议 |
50mg | 电议 |
100mg | 电议 |
200mg | 电议 |
500mg | 电议 |
生物活性 | Eliglustat is an specific, potent and orally activeglucocerebroside synthaseinhibitor with anIC50of 24 nM. | ||||||||||||||||
IC50& Target | IC50: 24 nM (glucocerebroside synthase)[1] | ||||||||||||||||
体外研究 (In Vitro) | Eliglustat tartrate shows good potency with an IC50of 24 nM and specificity against the target enzyme[1].Incubating K562 or B16/F10 cells for 72 h with increasing amounts of Genz-112638 (0.6-1000 nM) results in a dose-dependent reduction of cell surface levels of both GM1 and GM3. The mean IC50value for inhibiting the cell surface presentation of GM1 in K562 cells was 24 nM (range 14-34 nM) and that for GM3 in B16/F10 cells was 29 nM (range 12-48 nM)[1]. | ||||||||||||||||
体内研究 (In Vivo) | Mice that received drug prior to significant accumulation of substrate (10 weeks of age) showed reduced levels of glucosylceramide and number of Gaucher cells in the spleen, lung and liver when compared to age-matched control animals[1]. | ||||||||||||||||
Clinical Trial | |||||||||||||||||
分子量 | 404.54 | ||||||||||||||||
性状 | Solid | ||||||||||||||||
Formula | C23H36N2O4 | ||||||||||||||||
CAS 号 | 491833-29-5 | ||||||||||||||||
中文名称 | 依利格鲁司特 | ||||||||||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||||||||||
储存方式 |
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溶解性数据 | In Vitro: DMSO : 100 mg/mL(247.19 mM;Need ultrasonic) 配制储备液
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以下溶剂前显示的百
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