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NGB 2904
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
NGB 2904图片
CAS NO:189060-98-8
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
200mg电议

产品介绍
NGB 2904 是一种具有口服活性和选择性的多巴胺(DA) D3受体拮抗剂。NGB 2904 可用于可卡因成瘾的研究。
生物活性

NGB 2904 is an orally active and selectivedopamine (DA)D3receptorantagonist. NGB 2904 can be used for the research of cocaine addiction[1].

IC50& Target[1]

D3Receptor

 

体内研究
(In Vivo)

NGB 2904 (0.1~5 mg/kg; i.p.) significantly loweres the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibits cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration[1].
NGB 2904 (0~10 mg/kg; i.p.) administered 30 min prior to the beginning of daily cocaine self-administration sessions has no significant effect on cocaine self-administration behavior at a unit cocaine reinforcement dose of 0.5 mg/kg/infusion compared to vehicle-treated animals. NGB 2904 (0.1 and 1 mg/kg) pretreatment significantly inhibits the enhanced brain stimulation reward produced by 2 mg/kg, but not by 10 mg/kg, of cocaine. NGB 2904 pretreatment produces a significant attenuation of this cocaine-triggered reinstatement of drug-seeking[1].

Animal Model:Male Long–Evans rats (250–300 g)[1]
Dosage:0.1~5 mg/kg
Administration:I.p.;
Result:Significantly lowered the break-point for cocaine self-administration behavior reinforced under progressive-ratio conditions and significantly inhibited cocaine-triggered reinstatement of drug-seeking behavior in rats extinguished from daily cocaine self-administration.
分子量

494.46

性状

Solid

Formula

C28H29Cl2N3O

CAS 号

189060-98-8

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
In Vitro: 

Ethanol : 4.55 mg/mL(9.20 mM;ultrasonic and warming and heat to 60℃)

配制储备液
浓度溶剂体积质量1 mg5 mg10 mg
1 mM2.0224 mL10.1120 mL20.2241 mL
5 mM0.4045 mL2.0224 mL4.0448 mL
10 mM---------
*

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80℃, 6 months; -20℃, 1 month (protect from light)。-80℃ 储存时,请在 6 个月内使用,-20℃ 储存时,请在 1 个月内使用。