CAS NO: | 2410557-00-3 |
规格: | ≥98% |
包装 | 价格(元) |
1mg | 电议 |
2mg | 电议 |
5mg | 电议 |
10mg | 电议 |
25mg | 电议 |
iRucaparib-AP6 is a novel and potent PARP1 degrader based on PROTAC (Proteolysis-targeting chimera) technology. It is composed of Rucaparib as the warhead to bind PARP1 and pomalidomide to recruit the E3 ligase. iRucaparib-AP6 blocks the enzymatic activity of PARP1 in vitro, and PARP1-mediated poly-ADP-ribosylation signaling in intact cells. This strategy mimics PARP1 genetic depletion, which enables the pharmacological decoupling of PARP1 inhibition from PARP1 trapping. Finally, by depleting PARP1, iRucaparib-AP6 protects muscle cells and primary cardiomyocytes from DNA-damage-induced energy crisis and cell death.
纯度:≥98%
CAS:2410557-00-3