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iRucaparib-AP6
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
iRucaparib-AP6图片
CAS NO:2410557-00-3
规格:≥98%
包装与价格:
包装价格(元)
1mg电议
2mg电议
5mg电议
10mg电议
25mg电议

产品介绍

iRucaparib-AP6 is a novel and potent PARP1 degrader based on PROTAC (Proteolysis-targeting chimera) technology. It is composed of Rucaparib as the warhead to bind PARP1 and pomalidomide to recruit the E3 ligase. iRucaparib-AP6 blocks the enzymatic activity of PARP1 in vitro, and PARP1-mediated poly-ADP-ribosylation signaling in intact cells. This strategy mimics PARP1 genetic depletion, which enables the pharmacological decoupling of PARP1 inhibition from PARP1 trapping. Finally, by depleting PARP1, iRucaparib-AP6 protects muscle cells and primary cardiomyocytes from DNA-damage-induced energy crisis and cell death.

纯度:≥98%

CAS:2410557-00-3