FTI-2148 diTFA, a RAS C-terminal mimetic, is a
novel, potent and highly selective dual inhibitor of farnesyl
transferase (FT-1) and geranylgeranyl transferase-1 (GGT-1) with IC50s
of 1.4 nM and 1.7 μM, respectively. It has potential antitumor
activity. FTI-2148 suppressed the growth of the human lung
adenocarcinoma A-549
cells in nude mice by 33, 67, and 91% in a dose-dependent manner.
Combination therapy of FTI-2148 with either cisplatin, gemcitabine, or
Taxol resulted in a greater antitumor efficacy than monotherapy.
纯度:≥98%
CAS:817586-01-9