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Ziconotide
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ziconotide图片
CAS NO:107452-89-1
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
SNX-111
产品介绍
Ziconotide (SNX-111) 是一种肽,是一种有效且选择性的 N 型钙通道 (N-type calcium channels) 拮抗剂阻断剂。Ziconotide 减少突触传递,并可用于慢性疼痛研究。
生物活性

Ziconotide (SNX-111), a peptide, is a potent and selective block ofN-type calcium channelsantagonist. Ziconotide reduces synaptic transmission, and can be used for chronic pain research[1].

IC50& Target[1]

N-type calcium channel

 

体外研究
(In Vitro)

Most native cells express a variety of different calcium channels and as a result, Ziconotide only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes[1].
Ziconotide delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission[1].

体内研究
(In Vivo)

Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE)[2].

Animal Model:Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein[2]
Dosage:25 pmol/site, 50 pmol/site, 100 pmol/site
Administration:Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
Result:Significantly reduced the mechanical hypersensitivity in animals with EAE.
Clinical Trial
分子量

2639.13

Formula

C102H172N36O32S7

CAS 号

107452-89-1

Sequence Shortening

CKGKGAKCSRLMYDCCTGSCRSGKC-NH2 (Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)

中文名称

齐考诺肽

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.