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Ziconotide TFA
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Ziconotide TFA图片
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议

产品名称
SNX-111 TFA
产品介绍
Ziconotide TFA (SNX-111 TFA) 是一种肽,是一种有效且选择性的 N 型钙通道 (N-type calcium channels) 拮抗剂阻断剂。Ziconotide TFA 减少突触传递,并可用于慢性疼痛研究。
生物活性

Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block ofN-type calcium channelsantagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research[1].

IC50& Target[1]

N-type calcium channel

 

体外研究
(In Vitro)

Most native cells express a variety of different calcium channels and as a result, Ziconotide TFA only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide TFA also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes[1].
Ziconotide TFA delivers its antinociceptive efficacy by reducing the release of pronociceptive neurotransmitters in the dorsal horn of the spinal cord, thereby inhibiting pain signal transmission[1].

体内研究
(In Vivo)

Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) TFA reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE)[2].

Animal Model:Female C57BL/6mice (18-22 g, 6-8 weeks old) injected with myelin oligodendrocytes glycoprotein[2]
Dosage:25 pmol/site, 50 pmol/site, 100 pmol/site
Administration:Intrathecal injection; on the 4 th, 10 th, 15 th, 20 th, and 24 th days
Result:Significantly reduced the mechanical hypersensitivity in animals with EAE.
Clinical Trial
分子量

3437.30

Formula

C116H179F21N36O46S7

Sequence Shortening

CKGKGAKCSRLMYDCCTGSCRSGKC-NH2(Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25)

中文名称

齐考诺肽TFA

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.