包装 | 价格(元) |
100mg | 电议 |
250mg | 电议 |
500mg | 电议 |
生物活性 | Ziconotide TFA (SNX-111 TFA), a peptide, is a potent and selective block ofN-type calcium channelsantagonist. Ziconotide TFA reduces synaptic transmission, and can be used for chronic pain research[1]. | ||||||||
IC50& Target[1] |
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体外研究 (In Vitro) | Most native cells express a variety of different calcium channels and as a result, Ziconotide TFA only partially reduces high-voltage-activated calcium currents in differentiated human neuroblastoma IMR32 cells, rat superior cervical ganglion neurons, and rat hippocampal neurons. Ziconotide TFA also reduces calcium currents that result from expression of the α1B subunit in HEK cells, tsa-201 cells, and Xenopus laevis oocytes[1]. | ||||||||
体内研究 (In Vivo) | Ziconotide (i.t.; 25-100 pmol/site; 5 μL; on the 4 th, 10 th, 15 th, 20 th, and 24 th days) TFA reduces the levels of IL-1β and IL-23 in the CNS, as well as IL-17 production in the spleen, 25 days after MOG35-55-elicited EAE, in the mouse model of experimental autoimmune encephalomyelitis (EAE)[2].
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Clinical Trial | |||||||||
分子量 | 3437.30 | ||||||||
Formula | C116H179F21N36O46S7 | ||||||||
Sequence Shortening | CKGKGAKCSRLMYDCCTGSCRSGKC-NH2(Disulfide bridge:Cys1-Cys16;Cys8-Cys20;Cys15-Cys25) | ||||||||
中文名称 | 齐考诺肽TFA | ||||||||
运输条件 | Room temperature in continental US; may vary elsewhere. | ||||||||
储存方式 | Please store the product under the recommended conditions in the Certificate of Analysis. |