MST-312 是一种端粒酶抑制剂，可用于多发性骨髓瘤等癌症研究。

MST-312 is an inhibitor of telomerase and can be used in studies about cancer, such as multiple myeloma.

In U-266 cells, MST-312 (2 μM) upregulates the pro-apoptotic gene Bax and down-regulates the anti-apoptotic gene Bcl-2 and suppresses the expression of c-Myc and hTERT genes. MST-312 (2-8 μM) reduces cellular viability in a dose dependent and time-dependent manner. MST-312 (2-8 μM) induces cell apoptosis in a dose-dependent manner[1].

368449-04-1

C20H16N2O6

380.356

Telomerase Inhibitor IX

DMSO:70 mg/mL (184.04 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years