PP58 是 PDGFR、FGFR 和 Src 家族的抑制剂。

PP58 is an inhibitor of PDGFR, FGFR and Src family.

PP58 inhibits anisomycin-activated p38 in a dose-dependent manner with an IC50< 10 nM. LPS-stimulated TNF-α production is potently inhibited by PP58 with a cellular IC50 value of 3 nM[1].

PP58 exhibits some degree of selectivity in vivo[1].

212391-58-7

C22H19Cl2N5O2

456.33

DMSO:56.3mg/mL (123.3mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years