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Gallic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Gallic acid图片
CAS NO:149-91-7
包装与价格:
包装价格(元)
50 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Gallate
Benzoic Acid
3,4,5-Trihydroxybenzoic acid
没食子酸
产品介绍
Gallic acid 是一种天然多羟基酚类化合物,具有抑制环氧合酶-2 的自由基清除作用,还具有抗菌、抗氧化、抗菌、抗炎和抗肿瘤活性。

产品描述

Gallic acid is found in almost all plants. Plants known for their high gallic acid content include gallnuts,grapes,tea,hops and oak bark.

体外活性

Gallic acid does not protect against H(2)O(2)-induced PC12 cell death. It reduced the viability of PC12 cells in a dose-dependent manner. Gallic acid also induces cleavage of poly (ADP-ribose) polymerase, which is strongly related to apoptosis in neurons. Gallic acid induces the phosphorylation of c-Jun N-terminal protein kinase (JNK) and the downregulation of Bcl-2 in PC12 cells. Gallic acid leads to a progressive reduction in the viability of vector-transfected PC12 cells, which is delayed in PC12 cells that overexpressed Bcl-2[2].

体内活性

Gallic acid effectively protects rat erythrocytes. The antioxidant effect of the compound at the tested dosage in vivo was more prevalent than its prooxidative effects. Gallic acid has ameliorative effect on lipid peroxidation in vivo[1].

细胞实验

Cell viability is measured using the MTT assay. PC12 cells are incubated at 37?C with Water2 or gallic acid at different concentrations for 24 h with or without pretreatment with resveratrol. They are then treated with the MTT solution (final concentration, 1 mg/mL) for 2 h. The dark-blue formazan crystals that formed in intact cells are dissolved in DMSO, and the absorbance at 570 nm is measured using a micro-ELISA reader.(Only for Reference)

Cas No.

149-91-7

分子式

C7H6O5

分子量

170.12

别名

Gallate;Benzoic acid;3,4,5-Trihydroxybenzoic acid;没食子酸

储存和溶解度

H2O:7 mg/mL (41.15 mM)
Ethanol:32 mg/mL (188.1 mM)
DMSO:32 mg/mL (188.1 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years