BI-3802 能够抑制 BCL6 的Bric-à-brac (BTB) 结构域，IC50 ≤3 nM。它可诱导 BCL6 蛋白聚集，并促进 E3 连接酶SIAH1介导的蛋白降解。BI-3802显示出抗肿瘤活性。

BI-3802 is a highly potent BCL6 degrader and inhibits the Bric-à-brac (BTB) domain of BCL6 with an IC50 value of ≤3 nM. BI-3802 induces the polymerization of BCL6 and promotes BCL6 degration depended on E3 ligase SIAH1. BI-3802 has antitumor activity[1][2].

BI-3802 shows an IC50 of 43 nM for the cellular BCL6[1]. BI-3802 increases the interaction between BCL6 and SIAH1 (EC50 = 64 nM)[2].

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