Anamorelin hydrochloride 是生长素受体激动剂，根据FLIPR 检测，得到EC50=0.74 nM。

Anamorelin hydrochloride is a novel ghrelin receptor agonist(EC50 : 0.74 nM, in the FLIPR assay).

In rats, AnaMorelin hydrochloride(ANAM) significantly and dose-dependently increased FI and BW at all dose levels compared with control, and significantly increased GH levels at 10 or 30 mg/kg doses. Increases in GH and IGF-1 levels were observed following ANAM administration in pigs[1].

Fluorescent imaging plate reader and binding assays in HEK293 and baby hamster kidney cells determined the agonist and antagonist activity of ANAM, and its affinity for the ghrelin receptor. Rat pituitary cells were incubated with ANAM to evaluate its effect on growth hormone (GH) release. In vivo, rats were treated with ANAM 3, 10, or 30 mg/kg, or control orally, once daily for 6 days to evaluate the effect on food intake (FI) and body weight (BW), and once to assess GH response. In pigs, single (3.5 mg/kg) or continuous (1 mg/kg/day) ANAM doses were administered to assess GH and insulin-like growth factor (IGF-1) response[1].

861998-00-7

C31H43ClN6O3

583.17

RC-1291 hydrochloride;阿拉莫林盐酸盐;ONO-7643 hydrochloride

DMSO:28 mg/mL (48.01 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years