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Nedocromil
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Nedocromil图片
CAS NO:69049-73-6
包装与价格:
包装价格(元)
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
200 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
FPL 59002
尼多克罗
产品介绍
Nedocromil对多种介质的作用或形成有抑制作用,包括组胺,前列腺素 D2和白三烯 C4。

产品描述

Nedocromil inhibits the action or formation of multiple mediators. Which including histamine, leukotriene C4 (LTC4), and prostaglandin D2 (PGD2).

体外活性

Nedocromil suppresses the release of histamine, LTC4, and PGD2 from mast cells challenged with antigen with IC30 values of 2.1 μM, 2.3 μM, and 1.9 μM, respectively. It also has anti-human IgE with IC30 values of 4.7 μM, 1.3 μM, and 1.3 μM, respectively[1].

体内活性

Nedocromil can obviously improve cardiac function in mice with diabetic cardiomyopathy, but the treatment cannot restore normal function. Nedocromil-treated diabetic mice display obviously improved heart function compared with controls. However, the cardiac function of Nedocromil-treated diabetic mice remains significantly impaired when compared with normal mice [2].

Cas No.

69049-73-6

分子式

C19H17NO7

分子量

371.34

别名

FPL 59002;尼多克罗

储存和溶解度

DMSO:16.67 mg/mL (44.89 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years