Braco-19 trihydrochloride 是一种端粒酶抑制剂，可阻止端粒酶的加帽和催化作用。 Braco-19 trihydrochloride 抑制 HAdV 病毒复制。

Braco-19 trihydrochloride is an inhibitor of telomerase and prevents the capping and catalytic action of telomerase. Braco-19 trihydrochloride inhibits HAdV virus replication.

The IC50 for BRACO-19 trihydrochloride (1.0-10 μM) in UXF1138L cells is 2.5 μM, the IC100 is 5 μM. BRACO-19 trihydrochloride (1 μM) dramatically reduces the expression of nuclear hTERT[3]. BRACO-19 trihydrochloride (0-40 μM) dose-dependently decreases the AdV virus growth in eGFP-transinfected HEK 293 cells. BRACO-19 trihydrochloride (0-150 μM) decreases band intensity in an increasing concentration-dependent manner[4].

In nude mice established UXF1138LX Xenografts, BRACO-19 trihydrochloride (2 mg/kg; i.p.) significantly inhibits tumor growth and shows marked single-agent antitumor activity. some animals in the group shows complete regressions (5 of 12 tumors)[3].

1177798-88-7

C35H46Cl3N7O2

703.14

BRACO19 3HCl

H2O:19.8mg/mL (28.2mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years