Homobutein 是 HDAC 和 NF-Κb 的双重抑制剂，IC50 分别为 190 和 38 μM。 Homobutein 是一种铁螯合剂，具有抗癌、抗炎、抗寄生虫和抗氧化活性。

Homobutein is a dual inhibitor of HDACs and NF-κB with IC50s of 190 and 38 μM. Homobutein is an iron chelator with anticancer, anti-inflammatory, antiparasite, and antioxidation activities.

Homobutein (1 μg/mL) inhibits the growth of Toxoplasma gondii by 19.48%[1] with IC50s of 15.0 and 16.1 μM for W2 and D6 strains of P. falciparum[2]. Homobutein (20 - 40 μM) inhibits the viability and TNFα-induced NF-κB activity of K562 cells[4].

34000-39-0

C16H14O5

286.28

2',4,4'-Trihydroxy-3-methoxychalcone;3-O-Methylbutein

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years