| CAS NO: | 1421227-53-3 |
| 包装: | 100mg |
| 市场价: | 3507元 |
| Cas No. | 1421227-53-3 |
| 化学名 | N-[6-[4-[2-[4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)anilino]-2-oxoethyl]phenoxy]pyrimidin-4-yl]cyclopropanecarboxamide |
| Canonical SMILES | CN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)CC3=CC=C(C=C3)OC4=NC=NC(=C4)NC(=O)C5CC5)C(F)(F)F |
| 分子式 | C29H31F3N6O3 |
| 分子量 | 568.59 |
| 溶解度 | ≥ 15.95mg/mL in DMSO |
| 储存条件 | Store at -20℃ |
| General tips | For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while. |
| Shipping Condition | Evaluation sample solution : ship with blue ice All other available size: ship with RT , or blue ice upon request |
| 产品描述 | WS6 is a small-molecule inducer of β cell proliferation [1]. β cells are a subset of cells in the pancreatic islets and play an important role in regulating glucose homeostasis through the production of insulin [1]. WS6 is a small-molecule inducer of β cell proliferation. In mouse β cell line R7T1, WS6 induced cell proliferation with EC50 value of 0.28 μM. WS6 was very active in primary human and rodent islets. In primary rat and human β cells, WS6 induced rat β cell proliferation with EC50 value of 0.4 μM and increased 4% of rat β cells and 3% of human β cells to proliferate. In intact islet cultures, WS6 significantly induced proliferation [1]. In cultured human islets, WS6 induced β cell proliferation and also α cell proliferation. However, WS6 didn’t influence the expression of β cell-specific transcription factors and the amount of insulin-positive β cells, which suggested that WS6 didn’t influence β cell differentiation and human islet cell viability [2]. In type 1 diabetes (T1D) mice, WS6 significantly reduced blood glucose and increased β cell proliferation from 3.8% to 6.4% [1]. References: |
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