(Rac)-WAY-161503 是一种有效的，选择性的，高亲和力的 5-HT2C 受体激动剂，Ki 为 4 nM，EC50 为 12 nM。(Rac)-WAY-161503 对 HT2C 的亲和力分别比 5-HT2A 和 5-HT2B 受体高。(Rac)-WAY-161503 具有抗肥胖和抗抑郁的作用。

(Rac)-WAY-161503 is a selective and high-affinity agonist of the 5-HT2C receptor (Ki: 4 nM; EC50: 12 nM), with anti-obesity and antidepressant effects.

In male C57BL/6J mice, (Rac)-WAY-161503 (3-30 mg/kg; i.p.) treatment dose-dependently decreases locomotor activity, an effect that is blocked by the 5-HT2C/2B antagonist SER-082. Additionally, in the 5-HT2A KO mice, the decreased locomotor activity produced by 10 mg/kg DOI is potentiated [1].

75704-24-4

C11H11Cl2N3O

272.13

DMSO:90mg/mL (330.7mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years