NMS-P715 是一种 ATP 竞争性MPS1选择性抑制剂，IC50值为 182 nM。

NMS-P715 is a highly selective and ATP-competitive MPS1 inhibitor(IC50 of 182 nM).

NMS-P715 (1 μM) inhibits the proliferation of HCT116 cells. And it causes mitotic acceleration in U2OS cells overexpressing YFP-α-tubulin, induces aneuploidy. NMS-P715 (0.5, 1 μM) affects mitotic checkpoint complex (MCC) stability and cdc20 ubiquitylation[1].

NMS-P715 (90 mg/kg, p.o.) is well tolerated and causes no signs of body weight loss or other overt toxicities in an A2780 ovary carcinoma xenograft model[1].

1202055-32-0

C35H39F3N8O3

676.73

DMSO:2 mg/mL (2.96 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years