DHODH-IN-12 是一种 Leflunomide 衍生物，也是一种二氢乳清酸脱氢酶 (DHODH) 的弱抑制剂，其 PKA 为 5.07。

DHODH-IN-12 is a leflunomide derivative and a weak dihydrorotate dehydrogenase (DHODH) inhibitor with a pKa of 5.07.

A compound structurally related to leflunomide was designed, which contained a furan ring. Compound 12a undergoes 4 ring cleavage under physiological pH conditions to obtain the corresponding cyanoxime DHODH-IN-12. DHODH-IN-12 has been analyzed as a DHODH inhibitor; its inefficiency may be due to the poor stereochemistry of the oxime substructure[1].

1263303-93-0

C10H9N3O2

203.2

(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years