LTURM34 是一种 DNA-PK 抑制剂，IC50 为 34 nM。它在广泛的肿瘤细胞系中显示出有效的抗增殖活性，对 DNA-PK 的选择性比 PI3K 高 170 倍。

LTURM34 is an inhibitor of DNA-PK with IC50 of 34 nM. LTURM34 displays effective antiproliferative activity in a wide range of tumor cell lines. LTURM34 shows 170-fold selectivity for DNA-PK over PI3K .

LTURM34 is more consistently active against the selected cell lines (11 of 16), but at best shows 54% inhibition against the HOP-92 non-small cell lung cancer line. LTURM34 displays effective inhibition of DNA-PK with excellent selectivity over the Class I PI3K isoforms (IC50s: 5.8 and 8.5 μM for PI3K β and δ, respectively) .

1879887-96-3

C24H18N2O3S

414.48

DMSO:60 mg/mL (144.76 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years