(R)-(-)-Rolipram 是一种 PDE4 抑制剂 Rolipram 的 R-对映异构体。

(R)-(-)-Rolipram is an R-enantiomer of Rolipram which is a PDE4 inhibitor.

The reduction of (R)-(-)-rolipram on cAMP hydrolysis and the increasement of adenylyl cyclase activator forskolin on cAMP synthesis in a dose-dependent manner inhibits caspase-1 cleavage and IL-1β secretion[1].

85416-75-7

C16H21NO3

275.34

(-)-Rolipram;(R)-Rolipram

DMSO:49 mg/mL (177.96 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years