PRT 4165 是有效的PRC1介导 H2A 泛素化的抑制剂。

PRT4165 is a potent PRC1-mediated H2A ubiquitylation inhibitor.

Inhibit the?in vitro?E3 ubiquitin ligase activity of RNF2 and a Bmi1/RNF2 complex and H2A/H2AX ubiquitination

Blocks polycomb repressor complex (PRC) 1-mediated histone H2A ubiquitination?in vitro?and?in vivo.

31083-55-3

C15H9NO2

235.24

PRT 4165;NSC600157

DMSO:23.5 mg/mL(100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years