Sodium Phenylbutyrate 是一种组蛋白去乙酰化酶和内质网应激抑制剂，可研究癌症和感染等疾病。

Sodium Phenylbutyrate, a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expression, decreased cellular proliferation, increased cell differentiation, and the induction of apoptosis in susceptible tumor cell populations.

在G93A转基因ALS小鼠中,Phenylbutyrate能够改善临床症状,提高存活.在G93A小鼠中,Phenylbutyrate诱导NF-κB p50的表达,下调细胞色素c 和半胱氨酸蛋白酶表达.亨廷顿氏病（HD）的转基因小鼠模型中,Phenylbutyrate增加脑组蛋白乙酰化和降低组蛋白甲基化水平.

在前列腺癌细胞中,Phenylbutyrate通过减弱细胞凋亡拮抗剂Bcl-X（L）,双链断裂修复蛋白DNA依赖性蛋白激酶,前列腺进展标记物小窝蛋白-1和促血管生成血管内皮生长因子的表达水平,诱导前列腺癌细胞凋亡。

1716-12-7

C10H11NaO2

186.186

苯丁酸钠;4-苯基丁酸钠盐;Sodium Phenylbutyrate;TriButyrate;Buphenyl

H2O:18.6 mg/mL (100 mM)
DMSO:4.7 mg/mL (25 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years