RBN012759 是选择性和具有口服活性的PARP14抑制剂，IC50值小于3 nM，可降低促肿瘤巨噬细胞功能并在肿瘤外植体中引发炎症反应，比对 monoPARPs 的选择性高 300 倍，比对 polyPARPs 的选择性高 1000 倍。

RBN012759, a potent and selective PARP14 inhibitor, decreases pro-tumor macrophage function and elicits inflammatory responses in tumor explants.

2360851-29-0

C19H23FN2O3S

378.46

DMSO:10 mM
Powder: -20°C for 3 years
In solvent: -80°C for 2 years