Picolinamide 被发现是大鼠胰岛细胞核聚 (ADP-核糖) 合成酶的强抑制剂。

Picolinamide is found to be a strong inhibitor of poly (ADP-ribose) synthetase of nuclei from rat pancreatic islet cells.

In AR-HEK293 cells stably expressing full-length hAR, ODM-201 inhibits human AR (hAR) with IC50 of 26 nM. ODM-201 inhibits VCaP cell proliferation with IC50 of 230 nM, while has no effect on the viability of AR-negative cell lines tested, DU-145 prostate cancer cells and H1581 lung cancer cells. [1]

Overnight treatment of rats with picolinamide, administered as a single injection (4 mmol/kg), inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles. There is only a small increase (1.5-fold) in renal cortical NAD content after picolinamide treatment[3].

1452-77-3

C6H6N2O

122.127

2-Carbamoylpyridine;2-Picolinamide;2-吡啶甲酰胺;2-Pyridinecarboxamide;Picolinoylamide

Ethanol:23 mg/mL (188.3 mM)
H2O:22 mg/mL (180.2 mM)
DMSO:23 mg/mL (188.3 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years