UPF 1069 是一种特异性PARP抑制剂，对 PARP-1 和 PARP-2 的IC50值分别为 8 和 0.3 μM。

UPF 1069 is a specific PARP2 inhibitor ( IC50: 0.3 μM). It is ~27-fold selective against PARP1.

UPF 1069 is a selective PARP2 inhibitor with IC50 of 0.3 μM while inhibiting PARP1 with IC50 of 8 μM. [1]

In organotypic hippocampal slices, PARP-2 inhibition with UPF-1069 (0.01-1 mM) causes a concentration-dependent exacerbation (up to 155%) of oxygen-glucose deprivation (OGD)-induced CA1 pyramidal cell death. Higher concentrations, acting on both PARP-1 and PARP-2, have no effect on OGD injury. In mouse mixed cortical cells exposed to OGD, UPF-1069 (1-10 mM) significantly reduces post-ischaemic damage. [1]

1048371-03-4

C17H13NO3

279.295

DMSO:27.9 mg/mL (100 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years