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Dapoxetine HCl(LY-210448 HCl)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Dapoxetine HCl(LY-210448 HCl)图片
CAS NO:129938-20-1
规格:≥98%
包装与价格:
包装价格(元)
50mg电议
100mg电议
250mg电议
500mg电议
1g电议
2g电议
5g电议
10g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)341.87
FormulaC21H23NO.HCl
CAS No.129938-20-1 (HCl);
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 68 mg/mL (198.9 mM)
Water: <1 mg/mL
Ethanol: 68 mg/mL (198.9 mM)
SMILES CodeCN(C)[C@@H](CCOC1=C2C=CC=CC2=CC=C1)C3=CC=CC=C3.[H]Cl
SynonymsLY-210448; Dapoxetine HCl; LY 210448; LY210448; Priligy
实验参考方法
In Vitro

In vitro activity: Dapoxetine not only reduces the peak amplitude of Kv4.3 currents but also accelerates the decay rate of current inactivation in a concentration-dependent manner. Dapoxetine decreases the integral of the Kv4.3 currents over the duration of a depolarizing pulse with an IC50 of 5.3 μM. Dapoxetine also causes a substantial acceleration in closed-state inactivation. Dapoxetine produces a significant use-dependent block, which is accompanied by a delayed recovery from inactivation of Kv4.3 currents. Dapoxetine decreases the peak amplitude of Kv1.5 currents and accelerates the decay rate of current inactivation in a concentration-dependent manner with an IC50 of 11.6 μM. Dapoxetine decreases the tail current amplitude and slows the deactivation process of Kv1.5, which results in a tail crossover phenomenon. Dapoxetine produces a use-dependent block of Kv1.5 at frequencies of 1 and 2 Hz and slowed the time course for recovery of inactivation. Dapoxetine also appears to be a useful adjunct to morphine, lowering the threshold for analgesia, although Dapoxetine itself has negligible analgesic activity. Dapoxetine is the D-enantiomer of LY 243917 and is 3.5 times more potent as a serotonin reuptake inhibitor than the L-enantiomer.

In Vivo
Animal model
Formulation & Dosage
ReferencesNeuropharmacology. 2012 Jun;62(7):2261-6; Naunyn Schmiedebergs Arch Pharmacol. 2012 Jul;385(7):707-16.