LY 345899 是叶酸的类似物,也是亚甲基四氢叶酸脱氢酶 (MTHFD1;DC301) 和MTHFD2抑制剂,其IC50值分别为 96 nM 和 663 nM,对MTHFD1的Ki=为 18 nM。
产品描述
LY 345899 is a Folate analog and is a methylenetetrahydrofolate dehydrogenase and MTHFD2 inhibitor (IC50: 96 nM and 663 nM, respectively and a Ki: 18 nM for MTHFD1).
Cas No.
10538-99-5
分子式
C20H21N7O7
分子量
471.42
储存和溶解度
DMSO:125 mg/mL (265.16 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years