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Spaglumic acid
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Spaglumic acid图片
CAS NO:3106-85-2
包装与价格:
包装价格(元)
10mg电议
50mg电议
100mg电议

产品介绍
Spaglumic Acid (N-Acetylaspartylglutamic acid) 是一种神经肽,在脑中以毫摩尔浓度存在。
Cas No.3106-85-2
别名异冬谷酸,N-Acetylaspartylglutamic acid
化学名(S)-2-((R)-2-acetamido-3-carboxypropanamido)pentanedioic acid
Canonical SMILESO=C([C@@H](CC(O)=O)NC(C)=O)N[C@H](C(O)=O)CCC(O)=O
分子式C11H16N2O8
分子量304.26
溶解度<30.43mg/ml in Water
储存条件Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
产品描述

Spaglumic Acid is a neuropeptide found in millimolar concentrations in brain.

Spaglumic Acid (N-Acetylaspartylglutamate; NAAG) is released upon depolarization by a Ca2+-dependent process and is an agonist at mGluR3 receptors and an antagonist at NMDA receptors. Spaglumic Acid is catabolized to N-acetylaspartate and glutamate primarily by glutamate carboxypeptidase II, which is expressed on the extracellular surface of astrocytes. The levels of Spaglumic Acid and the activity of carboxypeptidase II are altered in a regionally specific fashion in several neuropsychiatric disorders[1].

References:
[1]. Coyle JT. The nagging question of the function of N-acetylaspartylglutamate. Neurobiol Dis. 1997;4(3-4):231-8.