RO8191 是一种咪唑并萘啶化合物,是干扰素 (IFN) 受体激动剂。它直接与 IFNα/β 受体 2 结合,激活 IFN 刺激的基因表达和JAK/STAT磷酸化。它通过具有干扰素样活性发挥 cccDNA 调节剂作用,并具有抗HBV活性。
产品描述
RO8191 (CDM-3008), an imidazonaphthyridine compound, is an agonist of interferon (IFN) receptor.
体外活性
RO8191 strongly suppresses HCV replicon activity at 72 h in a dose-dependent manner. RO8191 reduces levels of the proteins HCV NS3 and NS4A, which are localized mainly in the perinuclear region of the replicon cells[1].
体内活性
RO8191 significantly induces antiviral genes Oas1b, Mx1, and Pkr in the livers of six-week-old C57BL/6J mice[1].
Cas No.
691868-88-9
分子式
C14H5F6N5O
分子量
373.218
别名
CDM-3008;RO4948191
储存和溶解度
DMSO:3 mg/mL (8.04 mM),ultrasonic and warming and heat to 60°C
Powder: -20°C for 3 years
In solvent: -80°C for 2 years