Hirsutanonol 是来自桤木树皮的次生代谢物。 Hirsutanonol 具有有效的抗氧化和自由基清除活性,并对线粒体脂质过氧化具有抑制作用。 Hirsutanonol 可用于治疗特应性皮炎的研究。
产品描述
Hirsutanonol is a secondary metabolite from the bark of Alnus glutinosa. Hirsutanonol has potent antioxidant and free radical scavenging activities and exhibits an inhibition effect on mitochondrial lipid peroxidation. Hirsutanonol can be used for studies
体外活性
Hirsutanonol shows significant inhibitory effects on 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced cyclooxygenase-2 (COX-2) expression in immortalized human breast epithelial MCF10A cells. Hirustenone and hirsutanonol show promising anti-filarial activity both in vitro and in vivo studies.Hirsutanonol shows potent cytotoxic activities against murine B16 melanoma cells and human SNU-C1 gastric cancer cells, it also has a chemoprotective effect on human lymphocyte DNA. Hirsutanonol (1 μg/mL) decreased the frequency of micronuclei by 63.6 %, exerting a much stronger effect than the synthetic protector amifostine (17.2 %, 1 μg/mL)[1].
Cas No.
41137-86-4
分子式
C19H22O6
分子量
346.37
储存和溶解度
(< 1 mg/ml refers to the product slightly soluble or insoluble )
Powder: -20°C for 3 years
In solvent: -80°C for 2 years