(E)-[6]-Dehydroparadol 是 [6]-Shogaol 的氧化代谢产物，是有效的 Nrf2 活化剂。

(E)-[6]-Dehydroparadol, an oxidative metabolite of [6]-Shogaol, is a potent Nrf2 activator.

(E)-[6]-Dehydroparadol (5-80 μM; 24 h) inhibits the growth of HCT-116 and H-1299 cells, with IC50s of 43.02 and 41.59 μM, respectively. (E)-[6]-Dehydroparadol (10-40 μM; 24 h) induces apoptosis in HCT-116 and H-1299 cells[1].

(E)-[6]-Dehydroparadol (5 μM; 24 h) enhances Tg[glutathione S-transferase pi 1 (gstp1):green fluorescent protein (GFP)] fluorescence signal in the Tg(gstp1:GFP) transgenic zebrafish embryos[2].

878006-06-5

C17H24O3

276.37

(6)-Dehydroparadol

DMSO:120 mg/mL (434.2 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years