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OTX008
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
OTX008图片
CAS NO:286936-40-1
包装与价格:
包装价格(元)
1 mg电议
5 mg电议
10 mg电议
25 mg电议
50 mg电议
100 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
Calixarene 0118
PTX008
产品介绍
OTX008 是半乳糖凝集素 1 选择性抑制剂。

产品描述

OTX008 is a selective galectin-1 inhibitor.

体外活性

OTX008 inhibits Gal1 expression and ERK1/2 and AKT-dependent survival pathways in SQ20B and A2780-1A9 cells and induces G2/M cell cycle arrest through CDK1. OTX008 increases the anti-proliferative effects of Semaphorin-3A (Sema3A) in SQ20B cells and reverses invasion induced by exogenous Gal1. Growth inhibitory concentrations (GI50) of OTX008 range from 3 to 500 μM in a large panel of human solid tumor cell lines. A significant correlation between OTX008 GI50 values and Gal1 mRNA (LGALS1) and protein expression levels in the panel of cancer cells is observed. OTX008 affects endothelial cell proliferation, motility, invasiveness, and cord formation. Tumor cell proliferation is also inhibited, with differences in sensitivity among cell lines (IC50 from 1 to 190 μM)[1][2].

体内活性

OTX008 treatment is associated with the down-regulation of Gal1 and Ki67 in treated tumors, as well as decreased microvessel density and VEGFR2 expression. OTX008 inhibits the growth of A2780-1A9 xenografts. Combination studies display OTX008 synergy with several cytotoxic and targeted therapies, principally when OTX008 is administered first[1].

Cas No.

286936-40-1

分子式

C52H72N8O8

分子量

937.18

别名

Calixarene 0118;PTX008

储存和溶解度

Ethanol:33.33 mg/mL (35.56 mM)
DMSO:10 mg/mL (10.67 mM),Need ultrasonic
Powder: -20°C for 3 years
In solvent: -80°C for 2 years