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Arglabin
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Arglabin图片
CAS NO:84692-91-1
包装与价格:
包装价格(元)
5 mg电议
1 mL*10 mM(in DMSO)电议

产品名称
阿格拉宾
(+)-Arglabin
产品介绍
Arglabin 是从青蒿中分离出的一种天然产物,是一种 NLRP3 炎性体抑制剂,具有抗动脉粥样硬化和抗癌作用。

产品描述

Arglabin is a natural product isolated from Artemisia glabella, is a NLRP3 inflammasome inhibitor, has anti-atherogenic and anticancer effects.

体外活性

Arglabin-stimulated macrophages displayed a strong cytotoxic activity and the lowest doses (1.25 μg/mL and 0.125 μg/mL) induced a significant stimulation of cell mitochondrial metabolism, which correlated with [3H]TdR uptake by J774.1 cells under the same experimental conditions. Arglabin triggered the production of the three cytokines from J774-1 cells [1]. Arglabin exhibits anti exudative and antiproliferative properties on the models of acute aseptic inflammation caused by formalin, carrageenan, and histamine, and on the model of proliferative inflammation accompanying cotton-pellet granuloma [2]. Arglabin is able to reduce the proportion of AML stem cells (CD34+CD38-) in primary AML cells [3].

Cas No.

84692-91-1

分子式

C15H18O3

分子量

246.3

别名

阿格拉宾;(+)-Arglabin

储存和溶解度

DMSO:95 mg/mL (385.7 mM)
Powder: -20°C for 3 years
In solvent: -80°C for 2 years