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Risperidone(R-64766 Risperdal)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Risperidone(R-64766 Risperdal)图片
CAS NO:106266-06-2
规格:≥98%
包装与价格:
包装价格(元)
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议
1g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)410.48
FormulaC23H27FN4O2
CAS No.106266-06-2
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 4 mg/mL (9.7 mM)
Water: <1 mg/mL
Ethanol: 4 mg/mL (9.7 mM)
SMILES CodeO=C1C(CCN2CCC(C3=NOC4=CC(F)=CC=C34)CC2)=C(C)N=C5N1CCCC5
SynonymsR-64766; R64766; Risperidone, Risperidal, R 64766
实验参考方法
In Vitro

In vitro activity: Risperidone binds to both DA and serotonin (5HT) receptors, particularly in the neurons of striatal and limbic structures. Risperidone significantly affects brain nerve growth factor (NGF) level suggesting that it influences the turnover of endogenous growth factors. Risperidone significantly decreases BDNF concentrations in frontal cortex, occipital cortex and hippocampus and decreases or increases TrkB receptors in selected brain structures. Risperidone significantly increases D(2) binding in medial prefrontal cortex by 34% in rat forebrain regions. Risperidone produces even greater up-regulation of D(4) receptors in CPu (37%), NAc (32%), and HIP (37%) in rat forebrain regions. Risperidone significantly inhibits the production of NO and proinflammatory cytokines by activated microglia. Risperidone (1-50 mM) significantly enhances the intracellular accumulation of Rh123 in Caco-2 cells by inhibiting P-gp activity with an IC(50) value of 5.87 mM.

In VivoRisperidone does not significantly affect bodyweight gain (BWG), food intake(FI), glucose tolerance or leptin levels, even though prolactin and corticosterone are significantly elevated in male rats. Risperidone significantly increases BWG and FI in female rats. Risperidone (0.05 mg/kg) increases food intake and leptin gene expression in white adipose tissue (WAT), but the rate of bodyweight gain is not affected in rats. Risperidone (0.5 mg/kg) causes a reduction in bodyweight gain, as well as enhanced Ucp1 gene expression in BAT and serum prolactin concentrations in rats.
Animal modelRats
Formulation & Dosage0.05 mg/kg
References

J Neurosci Res. 2000 Jun 15;60(6):783-94; Brain Res. 2002 Dec 6;957(1):144-51.